This programming guidance is meant to inform programmes that aim to reduce HIV infection among adolescent girls and young women in countries and locations where HIV incidence is high among adolescent girls and young women and where HIV is primarily spread through heterosexual transmission. This report primarily is for policymakers, planners and implementers of HIV prevention programmes across multiple sectors, including organizations led by young people. The document also is useful for experts in wider health and social sector programmes, including health workers and teaching staff, or any other professionals who can integrate dimensions of HIV prevention into their area of work.